Background: Heat-and-pepsin-sensitive plant food allergens (PR-10 and profilin) sometimes cause systemic reaction. Objective: To detect the risk factors for systemic reactions induced by labile food allergens. Methods: A retrospective multicenter study was performed on patients with a documented history of systemic allergic reaction to labile plant food allergens and on age-matched controls with a history of oral allergy syndrome (OAS) induced by the same foods. Offending foods, their amount, and state (solid or liquid), and potential cofactors (nonsteroidal anti-inflammatory drugs, protonic pump inhibitors, exercise, alcohol, and fasting) were considered. Results: We studied 89 patients and 81 controls. Sensitization to PR-10 or profilin, IgE to Bet v 1 and/or Bet v 2, and foods causing OAS were similar in the two groups. Twenty patients experienced >1 systemic allergic reaction. Tree nuts, Rosaceae, Apiaceae, and soymilk were the main offending foods. Seventeen (19%) patients were taking a PPI when the systemic reaction occurred (vs 5% in controls; P <.025). The ingestion of the offending food in liquid form (soymilk) was frequent among patients (15%) but unusual among controls (2%; P [removed]

Systemic allergic reactions induced by labile plant-food allergens: Seeking potential cofactors. A multicenter study / Asero, R; Ariano, R; Aruanno, A; Barzaghi, C; Borrelli, P; Busa, M; Celi, G; Cinquini, M; Cortellini, G; D'Auria, F; De Carli, M; Di Paolo, C; Garzi, G; Rizzini, Fl; Magnani, M; Manzotti, G; Marra, A; Sopo, Sm; Murzilli, F; Nucera, E; Pinter, E; Pravettoni, V; Rivolta, F; Rizzi, A; Saporiti, N; Scala, E; Villalta, D; Yacoub, M; Zisa, G. - In: ALLERGY. - ISSN 0105-4538. - 76:5(2021), pp. 1473-1479. [10.1111/all.14634]

Systemic allergic reactions induced by labile plant-food allergens: Seeking potential cofactors. A multicenter study

Yacoub M
Penultimo
;
2021-01-01

Abstract

Background: Heat-and-pepsin-sensitive plant food allergens (PR-10 and profilin) sometimes cause systemic reaction. Objective: To detect the risk factors for systemic reactions induced by labile food allergens. Methods: A retrospective multicenter study was performed on patients with a documented history of systemic allergic reaction to labile plant food allergens and on age-matched controls with a history of oral allergy syndrome (OAS) induced by the same foods. Offending foods, their amount, and state (solid or liquid), and potential cofactors (nonsteroidal anti-inflammatory drugs, protonic pump inhibitors, exercise, alcohol, and fasting) were considered. Results: We studied 89 patients and 81 controls. Sensitization to PR-10 or profilin, IgE to Bet v 1 and/or Bet v 2, and foods causing OAS were similar in the two groups. Twenty patients experienced >1 systemic allergic reaction. Tree nuts, Rosaceae, Apiaceae, and soymilk were the main offending foods. Seventeen (19%) patients were taking a PPI when the systemic reaction occurred (vs 5% in controls; P <.025). The ingestion of the offending food in liquid form (soymilk) was frequent among patients (15%) but unusual among controls (2%; P [removed]
2021
anaphylaxis; food allergy; pollen allergy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/152066
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