Abstract: T cell-mediated adaptive immunity is designed to respond to non-self antigens andpathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1),Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine andautocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is oneof these mediators able to induce/inhibit immunological responses, playing a role in inflammatoryand autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenousand exogenous H2S modulate numerous important cell signaling pathways. In monocytes,polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization,adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, weoffer a comprehensive review on the role of H2S as a natural buffer able to maintain over time afunctional balance between Th1, Th2, Th17 and Treg immunological responses.

Buffering Adaptive Immunity by Hydrogen Sulfide / Pozzi, G; Gobbi, G; Masselli, E; Carubbi, C; Presta, V; Ambrosini, L; Vitale, M; Mirandola, P.. - In: CELLS. - ISSN 2073-4409. - 11:3(2022). [10.3390/cells11030325]

Buffering Adaptive Immunity by Hydrogen Sulfide

Vitale M
Penultimo
;
2022-01-01

Abstract

Abstract: T cell-mediated adaptive immunity is designed to respond to non-self antigens andpathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1),Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine andautocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is oneof these mediators able to induce/inhibit immunological responses, playing a role in inflammatoryand autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenousand exogenous H2S modulate numerous important cell signaling pathways. In monocytes,polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization,adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, weoffer a comprehensive review on the role of H2S as a natural buffer able to maintain over time afunctional balance between Th1, Th2, Th17 and Treg immunological responses.
2022
gasotransmitters
NaHS
cystathionine-synthase
cystathionine-lyase
sulphurous waters
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/154032
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