Bone marrow-derived mesenchymal stem cells (BM-MSCs) are valuable platforms for new therapies based on regenerative medicine. BM-MSCs era is coming of age since the potential of these cells is increasingly demonstrated. In fact, these cells give origin to osteoblasts, chondroblasts, and adipocyte precursors in vitro, and they can also differentiate versus other mesodermal cell types like skeletal muscle precursors and cardiomyocytes. In our short review, we focus on the more recent manipulations of BM-MSCs toward skeletal and heart muscle differentiation, a growing field of obvious relevance considering the toll of muscle disease (i.e., muscular dystrophies), the heavier toll of heart disease in developed countries, and the still not completely understood mechanisms of muscle differentiation and repair. © 2014 Daniela Galli et al.

Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: Facts and perspectives / Galli, Daniela; Vitale, Marco; Vaccarezza, Mauro. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - 2014:(2014), p. 762695. [10.1155/2014/762695]

Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: Facts and perspectives

VITALE, Marco;
2014-01-01

Abstract

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are valuable platforms for new therapies based on regenerative medicine. BM-MSCs era is coming of age since the potential of these cells is increasingly demonstrated. In fact, these cells give origin to osteoblasts, chondroblasts, and adipocyte precursors in vitro, and they can also differentiate versus other mesodermal cell types like skeletal muscle precursors and cardiomyocytes. In our short review, we focus on the more recent manipulations of BM-MSCs toward skeletal and heart muscle differentiation, a growing field of obvious relevance considering the toll of muscle disease (i.e., muscular dystrophies), the heavier toll of heart disease in developed countries, and the still not completely understood mechanisms of muscle differentiation and repair. © 2014 Daniela Galli et al.
2014
Adipocytes
Animals
Chondrocytes
Clinical Trials as Topic
Heart Diseases
Humans
Mesenchymal Stromal Cells
Muscle
Skeletal
Muscular Diseases
Osteoblasts
Regenerative Medicine
Cell Differentiation
Cell Lineage
Biochemistry
Genetics and Molecular Biology (all)
Immunology and Microbiology (all)
Medicine (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/154055
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