The HLA-B27 gene is strongly associated with the spondyloarthropathies (SpA), a group of chronic inflammatory diseases affecting the bowel, the joints, and the axial skeleton. Yet the basis for this association remains unknown, despite extensive study in the past years. The HLA-B27 transgenic rat spontaneously develops a disease that strikingly resembles human SpA. The purpose of this article is to review the contribution of studies on the HLA-B27 transgenic rat model aimed to elucidate the intimate relationship between gut and joint involvement in SpA.

HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides / A. F., Milia; Ibba, Lidia; Manetti, Mirko; Benelli, Gemma; Messerini, Luca; MATUCCI CERINIC, Marco. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1173:(2009), pp. 570-574.

HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides

MATUCCI CERINIC, MARCO
2009-01-01

Abstract

The HLA-B27 gene is strongly associated with the spondyloarthropathies (SpA), a group of chronic inflammatory diseases affecting the bowel, the joints, and the axial skeleton. Yet the basis for this association remains unknown, despite extensive study in the past years. The HLA-B27 transgenic rat spontaneously develops a disease that strikingly resembles human SpA. The purpose of this article is to review the contribution of studies on the HLA-B27 transgenic rat model aimed to elucidate the intimate relationship between gut and joint involvement in SpA.
2009
HLA-B27 transgenic rat
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/154235
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