Cardiomyopathy is among the leading causes of death from systemic sclerosis (SSc). Urokinase-type plasminogen activator receptor (uPAR)-deficient mice have been recently reported to display important histopathological hallmarks of SSc, including dermal fibrosis, reduced dermal capillary density, and pulmonary fibrosis. Here, we investigated whether uPAR-deficient mice could display the histopathological features of SSc-related cardiomyopathy.

Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice / Manetti, Mirko; Rosa, Irene; Fazi, Marilena; Guiducci, Serena; Carmeliet, Peter; Ibba, Lidia; MATUCCI CERINIC, Marco. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - 75:(2016), pp. 474-478. [10.1136/annrheumdis-2015-207803]

Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice

MATUCCI CERINIC, MARCO
2016-01-01

Abstract

Cardiomyopathy is among the leading causes of death from systemic sclerosis (SSc). Urokinase-type plasminogen activator receptor (uPAR)-deficient mice have been recently reported to display important histopathological hallmarks of SSc, including dermal fibrosis, reduced dermal capillary density, and pulmonary fibrosis. Here, we investigated whether uPAR-deficient mice could display the histopathological features of SSc-related cardiomyopathy.
2016
Cardiovascular Disease
Qualitative research
Systemic Sclerosis
Animal models
Fibrosis
Myocardium
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/154521
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