Abstract OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. RESULTS: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. CONCLUSION: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study / Ingegnoli, Francesca; Boracchi, Patrizia; Gualtierotti, Roberta; Smith, Vanessa; Cutolo, Maurizio; Foeldvari, Ivan; Airò, Paolo; Alegre Sancho, Juan Jose; Allanore, Yannick; Ananieva, Lidia P.; Ancuta, Codrina; Andrade, Luis Eduardo; Aringer, Martin; Becvar, Radim; Bojinca, Mihai; Butrimiene, Irena; Cantatore, Francesco Paolo; Caporali, Roberto; Caramaschi, Paola; Carreira, Patricia E.; Chirieac, Rodica; Corrado, Ada; Cosentino, Vanesa; Cuomo, Giovanna; Czirjak, Laszlo; Da Silva, José Antonio Pereira; de la Peña Lefebvre, Paloma García; De Keyser, Filip; de Souza Müller, Carolina; Damgaard, Kirsten; Damjanov, Nemanja; Denisov, Lev N.; Distler, Oliver; Doube, Alan; Dumitrascu, Alina; Engelhart, Merete; Exposito, Marta Valero; Eyerich, Kilian; Farge Bancel, Dominique; Azevedo, Valderílio Feijó; Foti, Rosario; Frerix, Marc; Gabrielli, Armando; Garen, Torhild; Gottschalk, Paola; Groseanu, Laura; Guiducci, Serena; Günther, Claudia; Hachulla, Eric; Hein, Rüdiger; Heitmann, Stefan; Henes, Jörg; Hesselstrand, Roger; Highton, John; Iannone, Florenzo; Ionescu, Ruxandra Maria; Kayser, Cristiane; Karpec, Diana; Kerzberg, Eduardo; Kotulska, Anna; Kopec Medrek, Magdalena; Kucharz, Eugene; Krummel Lorenz, Brigitte; Lauffer, Felix; Launay, David; Mengtao, Li; Litinsky, Ira; Loyo, Esthela; Cerinic, Marco Matucci; Meroni, Pierluigi; Midtvedt, Øyvind; Mihai, Carmen Marina; Montecucco, Carlomaurizio; Montoya, Fabiana; Morgiel, Ewa; Mouthon, Luc; Müller Ladner, Ulf; Nielsen, Henrik; Opris, Daniela; Ortiz Santamaria, Vera; Otsa, Kati; Pileckyte, Margarita; Pisarri, Simonetta; Popescu, Monica; Pozzi, Maria Rosa; Puppo, Francesco; Radominski, Sebastião Cezar; Riccieri, Valeria; Rosato, Edoardo; Rozman, Blaz; Rubio, Silvia Rodriguez; Rugiene, Rita; Saar, Petra; Salvador, Maria João; Seidel, Matthias; Sokolik, Renata; Solanki, Kamal; Stamenkovic, Bojana; Stankovic, Aleksandra; Stebbings, Simon; Strauss, Gitte; Sulli, Alberto; Szamosi, Szilvia; Szechinski, Jacek; Szmyrka Kaczmarek, Magdalena; Szücs, Gabriella; Tanaseanu, Cristina Mihaela; Tiglea, Isabela; Tyndall, Alan; Ughi, Nicola; Uprus, Maria; Vacca, Alessandra; Varju, Cecilia; Venalis, Algirdas; Venalis, Paulius; Walker, Ulrich A.; Widuchowska, Malgorzata; Wiland, Piotr; Dirk, M. Wuttge; Zeni, Silvana; Zenone, Thierry. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 102:(2015), pp. 19-24. [10.1016/j.mvr.2015.07.007]
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study
Cerinic, Marco Matucci;
2015-01-01
Abstract
Abstract OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. RESULTS: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. CONCLUSION: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
