Abstract OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. RESULTS: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. CONCLUSION: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study / Ingegnoli, Francesca; Boracchi, Patrizia; Gualtierotti, Roberta; Smith, Vanessa; Cutolo, Maurizio; Foeldvari, Ivan; Airò, Paolo; Alegre Sancho, Juan Jose; Allanore, Yannick; Ananieva, Lidia P.; Ancuta, Codrina; Andrade, Luis Eduardo; Aringer, Martin; Becvar, Radim; Bojinca, Mihai; Butrimiene, Irena; Cantatore, Francesco Paolo; Caporali, Roberto; Caramaschi, Paola; Carreira, Patricia E.; Chirieac, Rodica; Corrado, Ada; Cosentino, Vanesa; Cuomo, Giovanna; Czirjak, Laszlo; Da Silva, José Antonio Pereira; de la Peña Lefebvre, Paloma García; De Keyser, Filip; de Souza Müller, Carolina; Damgaard, Kirsten; Damjanov, Nemanja; Denisov, Lev N.; Distler, Oliver; Doube, Alan; Dumitrascu, Alina; Engelhart, Merete; Exposito, Marta Valero; Eyerich, Kilian; Farge Bancel, Dominique; Azevedo, Valderílio Feijó; Foti, Rosario; Frerix, Marc; Gabrielli, Armando; Garen, Torhild; Gottschalk, Paola; Groseanu, Laura; Guiducci, Serena; Günther, Claudia; Hachulla, Eric; Hein, Rüdiger; Heitmann, Stefan; Henes, Jörg; Hesselstrand, Roger; Highton, John; Iannone, Florenzo; Ionescu, Ruxandra Maria; Kayser, Cristiane; Karpec, Diana; Kerzberg, Eduardo; Kotulska, Anna; Kopec Medrek, Magdalena; Kucharz, Eugene; Krummel Lorenz, Brigitte; Lauffer, Felix; Launay, David; Mengtao, Li; Litinsky, Ira; Loyo, Esthela; Cerinic, Marco Matucci; Meroni, Pierluigi; Midtvedt, Øyvind; Mihai, Carmen Marina; Montecucco, Carlomaurizio; Montoya, Fabiana; Morgiel, Ewa; Mouthon, Luc; Müller Ladner, Ulf; Nielsen, Henrik; Opris, Daniela; Ortiz Santamaria, Vera; Otsa, Kati; Pileckyte, Margarita; Pisarri, Simonetta; Popescu, Monica; Pozzi, Maria Rosa; Puppo, Francesco; Radominski, Sebastião Cezar; Riccieri, Valeria; Rosato, Edoardo; Rozman, Blaz; Rubio, Silvia Rodriguez; Rugiene, Rita; Saar, Petra; Salvador, Maria João; Seidel, Matthias; Sokolik, Renata; Solanki, Kamal; Stamenkovic, Bojana; Stankovic, Aleksandra; Stebbings, Simon; Strauss, Gitte; Sulli, Alberto; Szamosi, Szilvia; Szechinski, Jacek; Szmyrka Kaczmarek, Magdalena; Szücs, Gabriella; Tanaseanu, Cristina Mihaela; Tiglea, Isabela; Tyndall, Alan; Ughi, Nicola; Uprus, Maria; Vacca, Alessandra; Varju, Cecilia; Venalis, Algirdas; Venalis, Paulius; Walker, Ulrich A.; Widuchowska, Malgorzata; Wiland, Piotr; Dirk, M. Wuttge; Zeni, Silvana; Zenone, Thierry. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 102:(2015), pp. 19-24. [10.1016/j.mvr.2015.07.007]

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Cerinic, Marco Matucci;
2015-01-01

Abstract

Abstract OBJECTIVE: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. RESULTS: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. CONCLUSION: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
2015
Capillaroscopy
EUSTAR
Juvenile systemic sclerosis
Microcirculation
Nailfold capillaroscopy
Systemic sclerosis
Videocapillaroscopy
Adolescent
Adult
Age of Onset
Aged
Capillaries
Child
Female
Humans
Male
Microscopic Angioscopy
Middle Aged
Retrospective Studies
Scleroderma
Localized
Scleroderma
Systemic
Young Adult
Biochemistry
Cardiology and Cardiovascular Medicine
Cell Biology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/154579
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