T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8+ CAR-T cells and the bifurcation of stem-like CD8+ CAR-T cells into effector and exhausted subsets, respectively.

Epigenetic checkpoints regulate the fate and function of CAR-T cells / Casucci, Monica; Bonini, Chiara; Ruggiero, Eliana. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 25:1(2024), pp. 4-6. [10.1038/s41590-023-01708-6]

Epigenetic checkpoints regulate the fate and function of CAR-T cells

Bonini, Chiara
Secondo
;
2024-01-01

Abstract

T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8+ CAR-T cells and the bifurcation of stem-like CD8+ CAR-T cells into effector and exhausted subsets, respectively.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/156676
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