T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8+ CAR-T cells and the bifurcation of stem-like CD8+ CAR-T cells into effector and exhausted subsets, respectively.
Epigenetic checkpoints regulate the fate and function of CAR-T cells / Casucci, Monica; Bonini, Chiara; Ruggiero, Eliana. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 25:1(2024), pp. 4-6. [10.1038/s41590-023-01708-6]
Epigenetic checkpoints regulate the fate and function of CAR-T cells
Bonini, ChiaraSecondo
;
2024-01-01
Abstract
T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8+ CAR-T cells and the bifurcation of stem-like CD8+ CAR-T cells into effector and exhausted subsets, respectively.File in questo prodotto:
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