Neurofilament light chain (NfL) is becoming increasingly notable in neurological diseases including AD, and it has been suggested as a new peripherical biomarker of neurodegeneration. We aimed to compare plasma NfL levels among Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), and AD patients and to evaluate relationships between NfL and CSF biomarkers and neuropsychological scores.

Plasma neurofilament light chain as a biomarker of Alzheimer's disease in Subjective Cognitive Decline and Mild Cognitive Impairment / Giacomucci, Giulia; Mazzeo, Salvatore; Bagnoli, Silvia; Ingannato, Assunta; Leccese, Deborah; Berti, Valentina; Padiglioni, Sonia; Galdo, Giulia; Ferrari, Camilla; Sorbi, Sandro; Bessi, Valentina; Nacmias, Benedetta. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - 269:8(2022), pp. 4270-4280. [10.1007/s00415-022-11055-5]

Plasma neurofilament light chain as a biomarker of Alzheimer's disease in Subjective Cognitive Decline and Mild Cognitive Impairment

Mazzeo, Salvatore
Secondo
;
2022-01-01

Abstract

Neurofilament light chain (NfL) is becoming increasingly notable in neurological diseases including AD, and it has been suggested as a new peripherical biomarker of neurodegeneration. We aimed to compare plasma NfL levels among Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), and AD patients and to evaluate relationships between NfL and CSF biomarkers and neuropsychological scores.
2022
Alzheimer’s disease
Mild Cognitive Impairment
Plasma neurofilament light chain
Subjective Cognitive Decline
Amyloid beta-Peptides
Biomarkers
Humans
Intermediate Filaments
Neurofilament Proteins
Neuropsychological Tests
tau Proteins
Alzheimer Disease
Cognitive Dysfunction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/156778
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