The association of cyclosporine A (CsA) with everolimus can exert synergistic effects on the alloimmune response. CsA inhibits the synthesis of interleukin-2 while everolimus inhibits the response to interleukin-2. Moreover, the interaction with CsA increases the bioavailability of everolimus. These data suggest that it is possible to reduce the doses of both drugs when given in combination.
Everolimus and Minimization of Cyclosporine in Renal Transplantation: 24-Month Follow-Up of the EVEREST Study / Ponticelli, C; Salvadori, M; Scolari, Mp; Citterio, F; Rigotti, Paolo; Veneziano, A; Bartezaghi, M.. - In: TRANSPLANTATION. - ISSN 0041-1337. - 91:(2011), pp. E72-E73. [10.1097/TP.0b013e318216c1db]
Everolimus and Minimization of Cyclosporine in Renal Transplantation: 24-Month Follow-Up of the EVEREST Study
RIGOTTI, PAOLO;
2011-01-01
Abstract
The association of cyclosporine A (CsA) with everolimus can exert synergistic effects on the alloimmune response. CsA inhibits the synthesis of interleukin-2 while everolimus inhibits the response to interleukin-2. Moreover, the interaction with CsA increases the bioavailability of everolimus. These data suggest that it is possible to reduce the doses of both drugs when given in combination.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
