CC-chemokine receptor 5 serves as the coreceptor for the HIV-1 R5 strains, which are responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene encoding this receptor (termed CCR5-Δ32) leads to the suppression of CC-chemokine receptor 5 presentation at the cell surface, thus impeding process of HIV entry into the cell. Individuals homozygous for the CCR5-Δ32 allele are resistant to infection with HIV-1 R5 strains, and are extremely rare among HIV-1-infected individuals. We have described a person homozygous for CCR5-Δ32, who was infected with subtype B HIV-1. Based on examination of proviral V3 sequences obtained from the first clinical blood sample within less than five months after seroconversion, the CXC-chemokine receptor 4-using strains (X4 or R5/X4) were detected. Data on HIV-1-infected patients homozygous for the CCR5-Δ32 allele, course of HIV-1 infection in these cases, and the infecting viral strains from current and all former reports on HIV-1 infection in CCR5-Δ32 homozygotes were gathered and compared. Identification of HIV-1-infected persons homozygous for CCR5-Δ32 supports the evidence that the lack of functional CC-chemokine receptor 5 at the cell surface does not confer absolute protection against HIV-1 infection, which should be considered when designing future HIV pre-exposure prophylaxis schemes based on CC-chemokine receptor 5 blocking drugs.
HIV-1 infection in persons homozygous for CCR5-Δ32 allele: The next case and the review / Smolen-Dzirba, J.; Rosinska, M.; Janiec, J.; Beniowski, M.; Cycon, M.; Bratosiewicz-Wasik, J.; Wasik, T. J.; Kelleher, T.; Cooper, D.; Grey, P.; Finlayson, R.; Bloch, M.; Ramacciotti, T.; Gelgor, L.; Smith, D.; Zangerle, R.; Gill, J.; Lutsar, I.; Chene, G.; Dabis, F.; Thiebaut, R.; Masquelier, B.; Costagliola, D.; Guiguet, M.; Vanhems, P.; Chaix, M. -L.; Ghosn, J.; Meyer, L.; Boufassa, F.; Hamouda, O.; Kucherer, C.; Bartmeyer, B.; Antoniadou, A.; Chrysos, G.; Daikos, G. L.; Touloumi, G.; Pantazis, N.; Katsarou, O.; Rezza, G.; Dorrucci, M.; Monforte, A. D.; De Luca, A.; Prins, M.; Geskus, R.; van der Helm, J.; Schuitemaker, H.; Sannes, M.; Brubakk, O.; Kran, A. -M. B.; Rosinska, M.; Muga, R.; Tor, J.; de Olalla, P. G.; Cayla, J.; del Amo, J.; Moreno, S.; Monge, S.; del Romero, J.; Perez-Hoyos, S.; Bucher, H. C.; Rickenbach, M.; Francioli, P.; Malyuta, R.; Murphy, G.; Sabin, C.; Porter, K.; Johnson, A.; Phillips, A.; Babiker, A.; Pillay, D.; Morrison, C.; Salata, R.; Mugerwa, R.; Chipato, T.; Amornkul, P. N.; Gilmour, J.; Kamali, A.; Karita, E.; Burns, F.; Giaquinto, C.; Gibb, D.; Grarup, J.; Kirk, O.; Kjaer, J.; Panteleev, A.; Reiss, P.; Thorne, C.; Aboulker, J. -P.; Albert, J.; Asandi, S.; De Wit, S.; De Wolf, F.; Gatell, J.; Karpov, I.; Ledergerber, B.; Lundgren, J.; Moller, C.; Rakhmanova, A.; Rockstroh, J.; Anne, A. V.; Dedes, N.; Fenton, K.; Pizzuti, D.; Vitoria, M.; Coughlin, K.; Faggion, S.; Fradette, L.; Frost, R.; Sabin, M.; Schwimmer, C.; Scott, M.. - In: AIDS REVIEWS. - ISSN 1139-6121. - 19:4(2017), pp. 219-230.
HIV-1 infection in persons homozygous for CCR5-Δ32 allele: The next case and the review
Rezza G.;
2017-01-01
Abstract
CC-chemokine receptor 5 serves as the coreceptor for the HIV-1 R5 strains, which are responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene encoding this receptor (termed CCR5-Δ32) leads to the suppression of CC-chemokine receptor 5 presentation at the cell surface, thus impeding process of HIV entry into the cell. Individuals homozygous for the CCR5-Δ32 allele are resistant to infection with HIV-1 R5 strains, and are extremely rare among HIV-1-infected individuals. We have described a person homozygous for CCR5-Δ32, who was infected with subtype B HIV-1. Based on examination of proviral V3 sequences obtained from the first clinical blood sample within less than five months after seroconversion, the CXC-chemokine receptor 4-using strains (X4 or R5/X4) were detected. Data on HIV-1-infected patients homozygous for the CCR5-Δ32 allele, course of HIV-1 infection in these cases, and the infecting viral strains from current and all former reports on HIV-1 infection in CCR5-Δ32 homozygotes were gathered and compared. Identification of HIV-1-infected persons homozygous for CCR5-Δ32 supports the evidence that the lack of functional CC-chemokine receptor 5 at the cell surface does not confer absolute protection against HIV-1 infection, which should be considered when designing future HIV pre-exposure prophylaxis schemes based on CC-chemokine receptor 5 blocking drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
