Objectives: To validate and assess the reliability of the Italian version of self-administered ALSFRS-R, considering patients’ clinical and cognitive features and caregiver’s help. Methods: During the COVID-19 pandemic, by analyzing the results of 70 paired self-administered vs standard telephone-administered ALSFRS-R, we calculated overall score, single item scores, ALSFRS-R domain scores, King’s and MiToS stage inter-rater agreement and reliability using different validated methods. We created the Italian version of self-administered ALSFRS-R following ENCALS recommendation. Results: Correlation between the two scales was 0.94 and no systematic directional bias was found. The intraclass correlation coefficient (ICC) was very high (>0.90) for the vast majority of the considered classification criteria, especially King’s total score (0.96) and MiToS score (0.94). A higher ICC was found when the patients answered the questionnaire with the caregiver’s help (0.95). Conclusions: Online self-administered ALSFRS-R scale is a valid tool to stratify ALS patients into clinical stages and to implement telemedicine monitoring.

Validation of the Italian version of self-administered ALSFRS-R scale / Manera, U.; Cabras, S.; Daviddi, M.; Vasta, R.; Torrieri, M. C.; Palumbo, F.; Bombaci, A.; Grassano, M.; Solero, L.; Peotta, L.; Iazzolino, B.; Canosa, A.; Calvo, A.; Chio, A.; Moglia, C.. - In: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. - ISSN 2167-8421. - 22:1-2(2020), pp. 151-153. [10.1080/21678421.2020.1813307]

Validation of the Italian version of self-administered ALSFRS-R scale

Bombaci A.;
2020-01-01

Abstract

Objectives: To validate and assess the reliability of the Italian version of self-administered ALSFRS-R, considering patients’ clinical and cognitive features and caregiver’s help. Methods: During the COVID-19 pandemic, by analyzing the results of 70 paired self-administered vs standard telephone-administered ALSFRS-R, we calculated overall score, single item scores, ALSFRS-R domain scores, King’s and MiToS stage inter-rater agreement and reliability using different validated methods. We created the Italian version of self-administered ALSFRS-R following ENCALS recommendation. Results: Correlation between the two scales was 0.94 and no systematic directional bias was found. The intraclass correlation coefficient (ICC) was very high (>0.90) for the vast majority of the considered classification criteria, especially King’s total score (0.96) and MiToS score (0.94). A higher ICC was found when the patients answered the questionnaire with the caregiver’s help (0.95). Conclusions: Online self-administered ALSFRS-R scale is a valid tool to stratify ALS patients into clinical stages and to implement telemedicine monitoring.
2020
ALSFRS-R
Amyotrophic lateral sclerosis
King’s staging system
MiToS staging system
telemedicine
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/159119
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