The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative responses. While vaccines form the frontline of defense, antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures, particularly for those unable or unwilling to be vaccinated. This review delves into the potential influence of nirmatrelvir on enduring immunity. In parallel, the potential of drug repurposing is explored, with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory properties. The importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

The interplay of drug therapeutics and immune responses to SARS-CoV-2 / Fumagalli, Valeria; Iannacone, Matteo. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 2042-0226. - 21:2(2024), pp. 197-200. [10.1038/s41423-023-01098-7]

The interplay of drug therapeutics and immune responses to SARS-CoV-2

Fumagalli, Valeria
Primo
;
Iannacone, Matteo
Ultimo
2024-01-01

Abstract

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative responses. While vaccines form the frontline of defense, antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures, particularly for those unable or unwilling to be vaccinated. This review delves into the potential influence of nirmatrelvir on enduring immunity. In parallel, the potential of drug repurposing is explored, with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory properties. The importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.
2024
Adaptive immunity
Bisphosphonates
Drug repurposing
Nirmatrelvir
SARS-CoV-2
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/159358
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