Introduction: Pancreatic Neuroendocrine Neoplasms (PanNENs) are characterized by a highly heterogeneous clinical and biological behavior, making their diagnosis challenging. PanNENs diagnostic work-up mainly relies on biochemical markers, pathological examination, and imaging evaluation. The latter including radiological imaging (i.e. computed tomography [CT] and magnetic resonance imaging [MRI]), functional imaging (i.e. 68Gallium [68 Ga]Ga-DOTA-peptide PET/CT and Fluorine-18 fluorodeoxyglucose [18F]FDG PET/CT), and endoscopic ultrasound (EUS) with its associated procedures. Areas covered: This review provides a comprehensive assessment of the recent advancements in the PanNENs diagnostic field. PubMed and Embase databases were used for the research, performed from inception to October 2023. Expert opinion: A deeper understanding of PanNENs biology, recent technological improvements in imaging modalities, as well as progresses achieved in molecular and cytological assays, are fundamental players for the achievement of early diagnosis and enhanced preoperative characterization of PanNENs. A multimodal diagnostic approach is required for a thorough disease assessment.

Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms / Battistella, Anna; Tacelli, Matteo; Mapelli, Paola; Schiavo Lena, Marco; Andreasi, Valentina; Genova, Luana; Muffatti, Francesca; De Cobelli, Francesco; Partelli, Stefano; Falconi, Massimo. - In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1747-4124. - (2024). [10.1080/17474124.2024.2342837]

Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms

Battistella, Anna
Primo
;
Tacelli, Matteo
Secondo
;
Mapelli, Paola;Andreasi, Valentina;Genova, Luana;Muffatti, Francesca;De Cobelli, Francesco;Partelli, Stefano
Penultimo
;
Falconi, Massimo
Ultimo
2024-01-01

Abstract

Introduction: Pancreatic Neuroendocrine Neoplasms (PanNENs) are characterized by a highly heterogeneous clinical and biological behavior, making their diagnosis challenging. PanNENs diagnostic work-up mainly relies on biochemical markers, pathological examination, and imaging evaluation. The latter including radiological imaging (i.e. computed tomography [CT] and magnetic resonance imaging [MRI]), functional imaging (i.e. 68Gallium [68 Ga]Ga-DOTA-peptide PET/CT and Fluorine-18 fluorodeoxyglucose [18F]FDG PET/CT), and endoscopic ultrasound (EUS) with its associated procedures. Areas covered: This review provides a comprehensive assessment of the recent advancements in the PanNENs diagnostic field. PubMed and Embase databases were used for the research, performed from inception to October 2023. Expert opinion: A deeper understanding of PanNENs biology, recent technological improvements in imaging modalities, as well as progresses achieved in molecular and cytological assays, are fundamental players for the achievement of early diagnosis and enhanced preoperative characterization of PanNENs. A multimodal diagnostic approach is required for a thorough disease assessment.
2024
PanNENs; diagnostic work-up; biomarkers; radiomics; molecular signatures; CE-EUS; EUS-E; [68Ga]Ga-DOTA-peptide PET; [18F]FDG PET; NETest
File in questo prodotto:
File Dimensione Formato  
Batistella_ Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms.pdf

embargo fino al 30/04/2025

Tipologia: Post-print (versione valutata in peer review)
Licenza: Creative commons
Dimensione 6.46 MB
Formato Adobe PDF
6.46 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/159417
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact