Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment / Pepin, M.; Klimkowicz-Mrowiec, A.; Godefroy, O.; Delgado, P.; Carriazo, S.; Ferreira, A. C.; Golenia, A.; Malyszko, J.; Grodzicki, T.; Giannakou, K.; Paolisso, G.; Barbieri, M.; Garneata, L.; Mocanu, C. A.; Liabeuf, S.; Spasovski, G.; Zoccali, C.; Bruchfeld, A.; Farinha, A.; Arici, M.; Capasso, G.; Wiecek, A.; Massy, Z. A.; Andrade, A.; Bachmann, M.; Bumblyte, I.; Covic, A. C.; Endlich, N.; Engvig, A.; Fouque, D.; Franssen, C.; Frische, S.; Gesualdo, L.; Goumenos, D.; Mani, L. -Y.; Marti, H. -P.; Mayer, C.; Nielsen, R.; Pesic, V.; Rroji, M.; Sakkas, G.; Stevens, K.; Vazelov, E.; Viggiano, D.; Zacharia, L.; Hoorn, E.; Figurek, A.; Unwin, R.; Wagner, C. A.; Wanner, C.; Nitsch, D.; Fridolin, I.; Hafez, G.; Soler Romeo, M. J.; Batinic, B.; Carrasco, L.; Gansevoort, R.; Martino, G.; Mattace Raso, F.; Nistor, I.; Ortiz, A.; Rastenyte, D.; Stefan, G.; Tedeschi, G.; Bikbov, B.; Endlich, K. H.; Kurganaite, J.; Perico, N.; Remuzzi, G.; Trepiccione, F.; Blankestijn, P.; Eckardt, K. -U.; Fliser, D.; Gutierrez-Jimenez, E.; Konig, M.; Rychlik, I.; Deleidi, M.; Reusz, G.; Farisco, M.; Perico, N.; Imenez Silva, P. H.; Bobot, M.; Capolongo, G.. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 30:9(2023), pp. 2899-2911. [10.1111/ene.15928]

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Martino G.;
2023-01-01

Abstract

Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.
2023
chronic kidney disease
cognition
dialysis
glomerular filtration rate
vascular risk factors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/159585
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