We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug.
Clinical improvement and normalized Th1 cytokine profile in early and long-term Interferon-alpha treatment in a suspected case of Hyper-IgE Syndrome
AIUTI , ALESSANDRO;AMBROSI , ALESSANDRO;RONCAROLO , MARIA GRAZIA;
2008-01-01
Abstract
We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug.File in questo prodotto:
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