PROGRAM DESCRIPTION The nose and paranasal sinuses may play host to a large range of systemic granulomatous diseases. The principal element of these diseases is granuloma formation consisting of a conglomerate of macrophages, epithelioid cells, and multinucleated giant cells. This configuration is present in a number of conditions, including infectious (spirochetes[syphilis, yaws], mycobacteria[tuberculosis, leprosy], bacteria[rhinoscleroma], and fungus[aspergillus]) and inflammatory (Wegener granulomatosis, sarcoidosis, Churg-Strauss syndrome, cocaine induced midline destructive lesions). Many of these lesions present with non-specific sinonasal symptoms and may progress rapidly to involve contiguous structures, such as the orbit and skull base, presenting significant clinical implications for timely diagnosis and management. Thorough diagnostic workup, including endoscopic, radiologic, histopathologic and serologic testing is imperative to arrive at the proper diagnosis and to initiate appropriate local and systemic treatment. Granulomatous diseases of the nose and sinuses represent an uncommon but clinically important and potentially lethal group of disorders encountered in otolaryngologic practice. A high index of suspicion, coupled with timely diagnosis and appropriate medical and surgical management, is required in this patient population. This miniseminar will introduce the participants to the current diagnostic and classification scheme of infectious, inflammatory, and neoplastic granulomatous conditions affecting the sinonasal tract. Pertinent endoscopic, radiologic and histologic findings will be highlighted in order to exemplify the typical clinical picture of these granulomatous diseases. Contemporary management strategies, including topical sinonasal and systemic therapies and the role of sinonasal surgery will be reviewed. The miniseminar faculty will be comprised of rhinologists with internationally recognized expertise in management of these disorders. Previous Section EDUCATIONAL OBJECTIVES 1) Understand the classification for infectious, inflammatory, and neoplastic granulomatous diseases of nose and sinuses. 2) Recognize the salient endoscopic, radiographic, histologic, and serologic features in patients with granulomatous disease. 3) Appreciate the appropriate medical and surgical management strategies in the patient population.
Granulomatous Diseases of the Nose and Paranasal Sinuses
TRIMARCHI , MATTEO;
2010-01-01
Abstract
PROGRAM DESCRIPTION The nose and paranasal sinuses may play host to a large range of systemic granulomatous diseases. The principal element of these diseases is granuloma formation consisting of a conglomerate of macrophages, epithelioid cells, and multinucleated giant cells. This configuration is present in a number of conditions, including infectious (spirochetes[syphilis, yaws], mycobacteria[tuberculosis, leprosy], bacteria[rhinoscleroma], and fungus[aspergillus]) and inflammatory (Wegener granulomatosis, sarcoidosis, Churg-Strauss syndrome, cocaine induced midline destructive lesions). Many of these lesions present with non-specific sinonasal symptoms and may progress rapidly to involve contiguous structures, such as the orbit and skull base, presenting significant clinical implications for timely diagnosis and management. Thorough diagnostic workup, including endoscopic, radiologic, histopathologic and serologic testing is imperative to arrive at the proper diagnosis and to initiate appropriate local and systemic treatment. Granulomatous diseases of the nose and sinuses represent an uncommon but clinically important and potentially lethal group of disorders encountered in otolaryngologic practice. A high index of suspicion, coupled with timely diagnosis and appropriate medical and surgical management, is required in this patient population. This miniseminar will introduce the participants to the current diagnostic and classification scheme of infectious, inflammatory, and neoplastic granulomatous conditions affecting the sinonasal tract. Pertinent endoscopic, radiologic and histologic findings will be highlighted in order to exemplify the typical clinical picture of these granulomatous diseases. Contemporary management strategies, including topical sinonasal and systemic therapies and the role of sinonasal surgery will be reviewed. The miniseminar faculty will be comprised of rhinologists with internationally recognized expertise in management of these disorders. Previous Section EDUCATIONAL OBJECTIVES 1) Understand the classification for infectious, inflammatory, and neoplastic granulomatous diseases of nose and sinuses. 2) Recognize the salient endoscopic, radiographic, histologic, and serologic features in patients with granulomatous disease. 3) Appreciate the appropriate medical and surgical management strategies in the patient population.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
