The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA and non-HLA genes with a marker density and sample size insufficient for mapping all independent association signals. We genotyped a panel of 1,472 SNPs to capture the common genomic variation across the 3.44 megabase (Mb) classic MHC region in 10,576 DNA samples derived from patients with systemic lupus erythematosus, Crohn's disease, ulcerative colitis, rheumatoid arthritis, myasthenia gravis, selective IgA deficiency, multiple sclerosis, and appropriate control samples. We identified the primary association signals for each disease and performed conditional regression to identify independent secondary signals. The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region.
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases / Rioux, J. D.; Goyette, P.; Vyse, T. J.; Hammarstrom, L.; Fernando, M. M. A.; Green, T.; De Jager, P. L.; Foisy, S.; Wang, J.; De Bakker, P. I. W.; Leslie, S.; Mcvean, G.; Padyukov, L.; Alfredsson, L.; Annese, V.; Hafler, D. A.; Pan-Hammarstrom, Q.; Matell, R.; Sawcer, S. J.; Compston, A. D.; Cree, B. A. C.; Mirel, D. B.; Daly, M. J.; Behrens, T. W.; Klareskog, L.; Gregersen, P. K.; Oksenberg, J. R.; Hauser, S. L.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 106:44(2009), pp. 18680-18685. [10.1073/pnas.0909307106]
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
Annese V.;
2009-01-01
Abstract
The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA and non-HLA genes with a marker density and sample size insufficient for mapping all independent association signals. We genotyped a panel of 1,472 SNPs to capture the common genomic variation across the 3.44 megabase (Mb) classic MHC region in 10,576 DNA samples derived from patients with systemic lupus erythematosus, Crohn's disease, ulcerative colitis, rheumatoid arthritis, myasthenia gravis, selective IgA deficiency, multiple sclerosis, and appropriate control samples. We identified the primary association signals for each disease and performed conditional regression to identify independent secondary signals. The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
