The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10 9), 22q12 (rs2412973, P = 1.55 × 10 9), 10q22 (rs1250550, P = 5.63 × 10 9), 2q37 (rs4676410, P = 3.64 × 10 8) and 19q13.11 (rs10500264, P = 4.26 × 10 10). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early-and adult-onset IBD. © 2009 Nature America, Inc. All rights reserved.
Common variants at five new loci associated with early-onset inflammatory bowel disease / Imielinski, M.; Baldassano, R. N.; Griffiths, A.; Russell, R. K.; Annese, V.; Dubinsky, M.; Kugathasan, S.; Bradfield, J. P.; Walters, T. D.; Sleiman, P.; Kim, C. E.; Muise, A.; Wang, K.; Glessner, J. T.; Saeed, S.; Zhang, H.; Frackelton, E. C.; Hou, C.; Flory, J. H.; Otieno, G.; Chiavacci, R. M.; Grundmeier, R.; Castro, M.; Latiano, A.; Dallapiccola, B.; Stempak, J.; Abrams, D. J.; Taylor, K.; Mcgovern, D.; Heyman, M. B.; Ferry, G. D.; Kirschner, B.; Lee, J.; Essers, J.; Grand, R.; Stephens, M.; Levine, A.; Piccoli, D.; Van Limbergen, J.; Cucchiara, S.; Monos, D. S.; Guthery, S. L.; Denson, L.; Wilson, D. C.; Grant, S. F. A.; Daly, M.; Silverberg, M. S.; Satsangi, J.; Hakonarson, H.. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:12(2009), pp. 1335-1340. [10.1038/ng.489]
Common variants at five new loci associated with early-onset inflammatory bowel disease
Annese V.;
2009-01-01
Abstract
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10 9), 22q12 (rs2412973, P = 1.55 × 10 9), 10q22 (rs1250550, P = 5.63 × 10 9), 2q37 (rs4676410, P = 3.64 × 10 8) and 19q13.11 (rs10500264, P = 4.26 × 10 10). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early-and adult-onset IBD. © 2009 Nature America, Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
