Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 × 10-13, combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 × 10-12, combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 × 10-16, combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 × 10-8, combined OR = 0.56; rs10889677, combined P = 1.3 × 10-8, combined OR = 1.29). © 2009 Nature America, Inc. All rights reserved.
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study / Silverberg, M. S.; Cho, J. H.; Rioux, J. D.; Mcgovern, D. P. B.; Wu, J.; Annese, V.; Achkar, J. -P.; Goyette, P.; Scott, R.; Xu, W.; Barmada, M. M.; Klei, L.; Daly, M. J.; Abraham, C.; Bayless, T. M.; Bossa, F.; Griffiths, A. M.; Ippoliti, A. F.; Lahaie, R. G.; Latiano, A.; Pare, P.; Proctor, D. D.; Regueiro, M. D.; Steinhart, A. H.; Targan, S. R.; Schumm, L. P.; Kistner, E. O.; Lee, A. T.; Gregersen, P. K.; Rotter, J. I.; Brant, S. R.; Taylor, K. D.; Roeder, K.; Duerr, R. H.. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:2(2009), pp. 216-220. [10.1038/ng.275]
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Annese V.;
2009-01-01
Abstract
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 × 10-13, combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 × 10-12, combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 × 10-16, combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 × 10-8, combined OR = 0.56; rs10889677, combined P = 1.3 × 10-8, combined OR = 1.29). © 2009 Nature America, Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
