We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24 ± 15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.
Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia / Annese, V.; Basciani, M.; Borrelli, O.; Leandro, G.; Simone, P.; Andriulli, A.. - In: MUSCLE & NERVE. - ISSN 0148-639X. - 21:11(1998), pp. 1540-1542. [10.1002/(SICI)1097-4598(199811)21:11<1540::AID-MUS27>3.0.CO;2-2]
Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia
Annese V.;
1998-01-01
Abstract
We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24 ± 15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
