CD8(+) T cells are crucial in controlling infection with hepatitis B virus (HBV) but are functionally impaired during chronic HBV infection. Traditionally, these functional deficits have been associated with classical T cell exhaustion due to persistent antigenic stimulation. However, recent findings challenge this concept, emphasizing the multifactorial nature of T cell dysfunction in HBV infection.
Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection / Thimme, R; Bertoletti, A; Iannacone, M. - In: NATURE REVIEWS IMMUNOLOGY. - ISSN 1474-1733. - 24:11(2024), pp. 775-776. [10.1038/s41577-024-01097-3]
Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection
Iannacone, M
Membro del Collaboration Group
2024-01-01
Abstract
CD8(+) T cells are crucial in controlling infection with hepatitis B virus (HBV) but are functionally impaired during chronic HBV infection. Traditionally, these functional deficits have been associated with classical T cell exhaustion due to persistent antigenic stimulation. However, recent findings challenge this concept, emphasizing the multifactorial nature of T cell dysfunction in HBV infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
