Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection / Astrid, Marchal; Elizabeth T., Cirulli; Iva, Neveux; Evangelos, Bellos; Ryan S., Thwaites; Kelly M., Schiabor Barrett; Yu, Zhang; Ivana, Nemes-Bokun; Mariya, Kalinova; Andrew, Catchpole; Stuart G., Tangye; Andra´s N., Spaan; Justin B., Lack; Jade, Ghosn; Charles, Burdet; Guy, Gorochov; Florence, Tubach; Pierre, Hausfater; Clifton L., Dalgard; Shen-Ying, Zhang; Qian, Zhang; Christopher, Chiu; Jacques, Fellay; Joseph J., Grzymski; Vanessa, Sancho-Shimizu; Laurent, Abel; Jean-Laurent, Casanova; Aure lie, Cobat; Alexandre, Bolze; Aiuti, A.; Casari, G.. - In: HGG ADVANCES. - ISSN 2666-2477. - 5:3(2024). [10.1016/j.xhgg.2024.100300]
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Aiuti A.Membro del Collaboration Group
;Casari G.Membro del Collaboration Group
2024-01-01
Abstract
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.| File | Dimensione | Formato | |
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