We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, suggesting that multidrug-resistant HIV does not significantly alter the size of the reservoir. These findings are a first step in studying the HIV-1 reservoir in the population with multidrug-resistant virus, and further studies are needed to confirm our results.
People with four-class drug-resistant HIV-1 may have low levels of intact DNA / Muccini, C.; Spagnuolo, V.; Zazzi, M.; Castagna, A.; Cesana, D.. - In: AIDS. - ISSN 0269-9370. - 39:4(2025), pp. 475-476. [10.1097/QAD.0000000000004066]
People with four-class drug-resistant HIV-1 may have low levels of intact DNA
Muccini C.
Primo
;Spagnuolo V.Secondo
;Castagna A.Penultimo
;
2025-01-01
Abstract
We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, suggesting that multidrug-resistant HIV does not significantly alter the size of the reservoir. These findings are a first step in studying the HIV-1 reservoir in the population with multidrug-resistant virus, and further studies are needed to confirm our results.| File | Dimensione | Formato | |
|---|---|---|---|
|
people_with_four_class_drug_resistant_hiv_1_may.20.pdf
solo gestori archivio
Tipologia:
PDF editoriale (versione pubblicata dall'editore)
Licenza:
Copyright dell'editore
Dimensione
857.79 kB
Formato
Adobe PDF
|
857.79 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
