Aim of study is to analyze Bromelain’ effects on the most common early complications after BCS (oedema and seroma). From January 2021 to December 2023 a double-blind randomized placebo-controlled trial was performed on 114 candidates for BCS at our Academic Unit. Group A received a supplement of Casperome™—Boswellia Phytosome® + Bromelain (CBB) in combination with alpha-lipoic acid + superoxide dismutase + B and D vitamins + centella asiatica. Group B received a supplement of CBB + placebo. Group C received placebo. The therapies were administrated for 30 days. On GEE logistic regression, drugs combination in A seems to be associated with statistical fewer oedema compared with C (P = 0.018 at 1 day and P = 0.002 after 1 month). Comparing B to C, B gained a significative value after 1 month (P = 0.007). On GEE logistic regression, the drugs combination in A has been associated with statistical fewer seroma compared with C (P = 0.009 at 15thpostoperative day and P < 0.001 after 1 month). B vs C reaches significant values 15 day and 1 month after surgery (P = 0.002 and P < 0.001, respectively). The current study is the first analyzing the employment of CBB association with/without neurotrophic agent on prevention of early complications after BCS.
Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery / Sgaramella, L. I.; Pasculli, A.; Moschetta, M.; Puntillo, F.; Dicillo, P.; Clemente, L.; Maruccia, M.; Mastropasqua, M. G.; Piombino, M.; Resta, N.; Rubini, G.; Prete, F. P.; Serio, G.; Stucci, L. S.; Giudice, G.; Testini, M.; Gurrado, Angela; Null, Null; Altini, C.; Amendolagine, M.; Angelini, C.; Caporusso, C.; Carrieri, A.; Deleo, C.; De Luca, G. M.; Deruvo, V.; Digiulio, G. L.; Elia, R.; Favetta, M.; Iuele, F.; Gentile, S.; Giglio, M.; Giorgio, A. M.; Grassi, T.; Lacalendola, E.; Lambo, M.; Lapadula, L.; Lavermicocca, W.; Lorusso, V.; Macchia, L.; Magno, A.; Mastrorillo, S.; Nitti, A.; Palma, F.; Pisani, A. R.; Poli, E.; Ronghi, V.; Solfrizzo, F.; Tedeschi, P.; Telegrafo, M.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 15:1(2025). [10.1038/s41598-025-86651-2]
Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
Mastropasqua, M. G.;
2025-01-01
Abstract
Aim of study is to analyze Bromelain’ effects on the most common early complications after BCS (oedema and seroma). From January 2021 to December 2023 a double-blind randomized placebo-controlled trial was performed on 114 candidates for BCS at our Academic Unit. Group A received a supplement of Casperome™—Boswellia Phytosome® + Bromelain (CBB) in combination with alpha-lipoic acid + superoxide dismutase + B and D vitamins + centella asiatica. Group B received a supplement of CBB + placebo. Group C received placebo. The therapies were administrated for 30 days. On GEE logistic regression, drugs combination in A seems to be associated with statistical fewer oedema compared with C (P = 0.018 at 1 day and P = 0.002 after 1 month). Comparing B to C, B gained a significative value after 1 month (P = 0.007). On GEE logistic regression, the drugs combination in A has been associated with statistical fewer seroma compared with C (P = 0.009 at 15thpostoperative day and P < 0.001 after 1 month). B vs C reaches significant values 15 day and 1 month after surgery (P = 0.002 and P < 0.001, respectively). The current study is the first analyzing the employment of CBB association with/without neurotrophic agent on prevention of early complications after BCS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
