We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2+ NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2- NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2+ NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.
KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients / Rizzo, R.; Bortolotti, D.; Fainardi, E.; Gentili, V.; Bolzani, S.; Baldi, E.; Casetta, I.; Granieri, E.; Rotola, A.; Furlan, R.; Di Luca, D.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 294:(2016), pp. 1-5. [10.1016/j.jneuroim.2016.03.007]
KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients
Furlan R.;
2016-01-01
Abstract
We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2+ NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2- NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2+ NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
