Significant tricuspid regurgitation (TR) is a relatively common condition, affecting approximately 4 % of the elderly population. However, there are currently no clear guidelines for its medical management due to a lack of sufficient data in the literature. This review examines the pathophysiology of TR, categorizes its etiologies, and evaluates therapeutic options, both pharmacological and non-pharmacological, to optimize intervention timing and hemodynamic management. Based on the etiology and severity of TR, we suggest a gradual, stage-based algorithm for diuretic therapy titration and a management approach derived from common clinical practices.

Therapeutical approach of tricuspid regurgitation and right heart failure / Godino, C.; Nemola, G.; Sisinni, A.; Margonato, D.; Fragasso, G.; Maisano, F.; Cavalcante, J.; Adamo, M.; Metra, M.; Margonato, A.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 429:(2025). [10.1016/j.ijcard.2025.133163]

Therapeutical approach of tricuspid regurgitation and right heart failure

Margonato D.;Maisano F.;Metra M.
Penultimo
;
Margonato A.
Ultimo
2025-01-01

Abstract

Significant tricuspid regurgitation (TR) is a relatively common condition, affecting approximately 4 % of the elderly population. However, there are currently no clear guidelines for its medical management due to a lack of sufficient data in the literature. This review examines the pathophysiology of TR, categorizes its etiologies, and evaluates therapeutic options, both pharmacological and non-pharmacological, to optimize intervention timing and hemodynamic management. Based on the etiology and severity of TR, we suggest a gradual, stage-based algorithm for diuretic therapy titration and a management approach derived from common clinical practices.
2025
Diuretics
Right heart failure
Tricuspid regurgitation
Valvular disease
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/190573
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