Istaroxime is a first-in-class agent which acts through inhibition of the sarcolemmal Na+ /K+ pump and activation of the SERCA2a pump. This study assessed the effects of a 24 h infusion of istaroxime in patients hospitalised for acute heart failure (AHF).

Treatment with 24 hour istaroxime infusion in patients hospitalised for acute heart failure: a randomised, placebo-controlled trial / Carubelli, V., Zhang, Y., Metra, M., Lombardi, C., Felker, G.M., Filippatos, G., O'Connor, C.M., Teerlink, J.R., Simmons, P., Segal, R., Malfatto, G., La Rovere, M.T., Li, D., Han, X., Yuan, Z., Yao, Y., Li, B., Lau, L.F., Bianchi, G., Zhang, J.. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1879-0844. - (2020). [10.1002/ejhf.1743]

Treatment with 24 hour istaroxime infusion in patients hospitalised for acute heart failure: a randomised, placebo-controlled trial

Metra, Marco;
2020-01-01

Abstract

Istaroxime is a first-in-class agent which acts through inhibition of the sarcolemmal Na+ /K+ pump and activation of the SERCA2a pump. This study assessed the effects of a 24 h infusion of istaroxime in patients hospitalised for acute heart failure (AHF).
2020
Acute heart failure
Istaroxime
Outcomes
SERCA2a
Therapy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/193090
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