Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in pulmonary and systemic hypertension, as well as ventricular dysfunction, through effects on vascular smooth muscle, the kidneys, and cardiomyocytes. We aimed to determine the association between serial ET-1 levels and acute heart failure patient outcomes.

Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy / Perez, Antonio L; Grodin, Justin L; Wu, Yuping; Hernandez, Adrian F; Butler, Javed; Metra, Marco; Felker, G Michael; Voors, Adriaan A; Mcmurray, John J; Armstrong, Paul W; Starling, Randall C; O'Connor, Christopher M; Tang, W H Wilson. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1388-9842. - 18:3(2016), pp. 290-297. [10.1002/ejhf.456]

Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy

Metra, Marco;
2016-01-01

Abstract

Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in pulmonary and systemic hypertension, as well as ventricular dysfunction, through effects on vascular smooth muscle, the kidneys, and cardiomyocytes. We aimed to determine the association between serial ET-1 levels and acute heart failure patient outcomes.
2016
Acute heart failure
Endothelin-1
Prognosis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/193423
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