Association of elevated circulating levels of trimethylamine N-oxide (TMAO) with adverse outcomes in patients with heart failure (HF) has been described. However, response of TMAO levels to treatment and medications has not been investigated. Therefore, we investigated whether TMAO levels are responsive to guideline-recommended treatment and medications, and further reflect changes in outcomes.

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF) / Suzuki, Toru; Yazaki, Yoshiyuki; Voors, Adriaan A; Jones, Donald J L; Chan, Daniel C S; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Hillege, Hans L; Lang, Chim C; Ponikowski, Piotr; Samani, Nilesh J; Van Veldhuisen, Dirk J; Zannad, Faiez; Zwinderman, Aeilko H; Metra, Marco; Ng, Leong L. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1879-0844. - (2018). [10.1002/ejhf.1338]

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF)

Metra, Marco;
2018-01-01

Abstract

Association of elevated circulating levels of trimethylamine N-oxide (TMAO) with adverse outcomes in patients with heart failure (HF) has been described. However, response of TMAO levels to treatment and medications has not been investigated. Therefore, we investigated whether TMAO levels are responsive to guideline-recommended treatment and medications, and further reflect changes in outcomes.
2018
Biomarker
Gut microbiome
Heart failure
Metabolite
Outcome study
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/193680
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