In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells / Mazzucchelli, Serena; Colombo, Miriam; Verderio, Paolo; Rozek, E; Andreata, F; Galbiati, Elisabetta; Tortora, Paolo; Corsi, F; Prosperi, Davide. - In: ANGEWANDTE CHEMIE. - ISSN 1521-3773. - 52:11(2013), pp. 3121-3125. [10.1002/anie.201209662]

Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells

Andreata, F;
2013-01-01

Abstract

In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
2013
multifunctional nanoparticles
homing peptides
uPAR
bioconjugation
cell targeting
bioconjugation
cell targeting
nanoparticles
peptides
receptors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/196187
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