Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients.

A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study / Lucenteforte, E.; Vagnoli, L.; Pugi, A.; Crescioli, G.; Lombardi, N.; Bonaiuti, R.; Arico, M.; Giglio, S.; Messeri, A.; Mugelli, A.; Vannacci, A.; Maggini, V.; Lombardi, Niccolo'. - In: BMC CANCER. - ISSN 1471-2407. - 18:(2018). [10.1186/s12885-018-4478-3]

A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study

Giglio S.;
2018-01-01

Abstract

Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients.
2018
Cancer pain
Children
Opioid efficacy
Opioid safety
Age factors
Analgesics
Opioid
Biological variation
Population
Cancer pain
Child
Humans
Longitudinal studies
Neoplasms
Pain measurement
Risk factors
Treatment outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/196275
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