Reticular erythematous mucinosis: a systematic review of a controversial entity

INTRODUCTION: Reticular erythematous mucinosis (REM) is a rare chronic dermatosis, predominantly affecting middle age women, characterized by net-like macules and patches on the chest and back. The etiology of REM is uncertain, though associations with environmental, hormonal, and autoimmune factors have been suggested. EVIDENCE ACQUISITION: This systematic review of 62 studies, involving 129 patients, analyzes the clinical, histopathological, and therapeutic aspects of REM. EVIDENCE SYNTHESIS: Findings indicate consistent mucin deposition in the dermis, a predominant lymphocytic infiltrate, and a frequent association with comorbidities like thyroid disorders and autoimmune diseases. Antimalarial medications, particularly hydroxychloroquine, are highlighted as the most effective treatment, though the disease may relapse upon cessation. CONCLUSIONS: This review emphasizes REM as a distinct clinical entity and underscores the need for further research to refine diagnostic criteria and treatment protocols.