Long-Term Stability Bio-Reconfigurable Differential Impedance Electronic Platform for Virus Diagnostic

This paper presents a portable and modular bioelectronic platform for multiplexed viral diagnostics, leveraging Differential Impedance Sensing (DIS) for labelfree detection. The electronic platform architecture supports rapid biofunctional reconfiguration, enabling simultaneous interrogation of multiple viral targets via site-specific immobilization of molecular recognition elements.Each chip integrates seven gold interdigitated microelectrode (IDE) sensing sites, whose impedance spectra have been characterized to ensure signal repeatability, and long-term stability. Experimental validation was conducted using a diverse set of bioprobes, with particular emphasis on viral nucleic acid and protein targets. The system’s adaptability and high-throughput capability make it wellsuited for point-of-care diagnostics and scalable screening applications, offering a versatile tool for next-generation multiplexed biosensing.