Background: Nutritional disorders may affect short-term recovery after major orthopaedic surgery, but evidence is lacking. This study assessed whether and how different nutritional disorders diagnosed at admission could influence early recovery after hip replacement. Methods: A prospective analytical study was designed to include 60 patients scheduled for elective primary hip replacement and assess their nutritional status to diagnose 5 malnutrition phenotypes: undernutrition, sarcopenia, obesity, sarcopenic obesity, and sarcopenic undernutrition. Outcome measures were 24 h change in neutrophils, 72 h change in haemoglobin, and 10-day gait speed regain. Results: Haemoglobin reached the nadir at day 2–3 and partially recovered by day 10 in all patients, with sarcopenia and undernutrition being the strongest predictors of the postoperative drop (−2.37 g∙dL−1 and −0.80 g∙dL−1, p < 0.05). Neutrophils peaked immediately after surgery and returned to baseline levels at discharge, with sarcopenic undernutrition displaying a blunted response after surgery (−16.20%, p < 0.01). Undernutrition was found to be the most influential preoperative variable on gait speed recovery, but with a marginal effect. None of the patients covered the reference energy and protein needs through diet in the 10 postoperative days. Conclusions: In this cohort, nutritional disorders with reduced body function and reserves (sarcopenia and undernutrition) grounded a greater vulnerability to surgery in terms of early stress response and short-term recovery. This calls for both advanced planning of nutritional prehabilitation strategies for these conditions and adequate postoperative nutritional support.

Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults / Briguglio, M., Latella Maria, L., Sirtori, P., Mangiavini, L., De Luca, P., Geroldi, M., De Vecchi, E., Lombardi, G., Petrillo, S., Wainwright, T., Peretti, G., Banfi, Giuseppe.. - In: NUTRIENTS. - ISSN 2072-6643. - 17:14(2025). [10.3390/nu17142319]

Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults

Banfi Giuseppe.
Ultimo
2025-01-01

Abstract

Background: Nutritional disorders may affect short-term recovery after major orthopaedic surgery, but evidence is lacking. This study assessed whether and how different nutritional disorders diagnosed at admission could influence early recovery after hip replacement. Methods: A prospective analytical study was designed to include 60 patients scheduled for elective primary hip replacement and assess their nutritional status to diagnose 5 malnutrition phenotypes: undernutrition, sarcopenia, obesity, sarcopenic obesity, and sarcopenic undernutrition. Outcome measures were 24 h change in neutrophils, 72 h change in haemoglobin, and 10-day gait speed regain. Results: Haemoglobin reached the nadir at day 2–3 and partially recovered by day 10 in all patients, with sarcopenia and undernutrition being the strongest predictors of the postoperative drop (−2.37 g∙dL−1 and −0.80 g∙dL−1, p < 0.05). Neutrophils peaked immediately after surgery and returned to baseline levels at discharge, with sarcopenic undernutrition displaying a blunted response after surgery (−16.20%, p < 0.01). Undernutrition was found to be the most influential preoperative variable on gait speed recovery, but with a marginal effect. None of the patients covered the reference energy and protein needs through diet in the 10 postoperative days. Conclusions: In this cohort, nutritional disorders with reduced body function and reserves (sarcopenia and undernutrition) grounded a greater vulnerability to surgery in terms of early stress response and short-term recovery. This calls for both advanced planning of nutritional prehabilitation strategies for these conditions and adequate postoperative nutritional support.
2025
Inglese
Multidisciplinary Digital Publishing Institute (MDPI)
17
14
17
Pubblicato
https://www.mdpi.com/2072-6643/17/14/2319
Esperti anonimi
Internazionale
Goal 3: Good health and well-being
enhanced recovery after surgery; malnutrition; orthopaedic procedures; patient care; postoperative complication; prehabilitation; quality improvement; sarcopenia; total hip replacement
Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults / Briguglio, M., Latella Maria, L., Sirtori, P., Mangiavini, L., De Luca, P., Geroldi, M., De Vecchi, E., Lombardi, G., Petrillo, S., Wainwright, T., Peretti, G., Banfi, Giuseppe.. - In: NUTRIENTS. - ISSN 2072-6643. - 17:14(2025). [10.3390/nu17142319]
open
12
info:eu-repo/semantics/article
262
Briguglio, Matteo; Latella Maria, Letizia; Sirtori, Paolo; Mangiavini, Laura; De Luca, Paola; Geroldi, Manuela; De Vecchi, Elena; Lombardi, Giovanni; ...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
File in questo prodotto:
File Dimensione Formato  
Influence of preoperative.pdf

accesso aperto

Tipologia: PDF editoriale (versione pubblicata dall'editore)
Licenza: Creative commons
Dimensione 2.06 MB
Formato Adobe PDF
2.06 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/199355
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact