Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-gamma sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface.
Sticky memories of an activated macrophage / Frosio, L.; Ostuni, R.. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 223:4(2026). [10.1084/jem.20252624]
Sticky memories of an activated macrophage
Frosio L.;Ostuni R.
2026-01-01
Abstract
Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-gamma sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface.File in questo prodotto:
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