We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.
Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry / Calcagno, A., Strano, M., Lolatto, R., Vercesi, R., Mandelli, A., Antonucci, M., Spagnuolo, V., Clemente, T., Francisci, D., Cenderello, G., Schioppa, O., Comi, L., Furlan, R., Castagna, A., Cinque, P.. - In: AIDS. - ISSN 0269-9370. - 40:7(2026), pp. 1045-1049. [10.1097/QAD.0000000000004483]
Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry
Strano M.;Spagnuolo V.;Clemente T.;Furlan R.;Castagna A.;
2026-01-01
Abstract
We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
