Neutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is detectable by routine clinical assays, independently of antibodies. Recognizing this capacity reframes correlates of protection and calls for vaccines that harness T cells as early, decisive defenders.
Abortive infection: T cells as early, antibody-independent defenders / Swadling, L., Fumagalli, V., Maini, M.K., Iannacone, M.. - In: NATURE REVIEWS IMMUNOLOGY. - ISSN 1474-1733. - 26:5(2026), pp. 327-329. [10.1038/s41577-026-01298-y]
Abortive infection: T cells as early, antibody-independent defenders
Fumagalli V.Secondo
;Iannacone M.
Ultimo
2026-01-01
Abstract
Neutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is detectable by routine clinical assays, independently of antibodies. Recognizing this capacity reframes correlates of protection and calls for vaccines that harness T cells as early, decisive defenders.File in questo prodotto:
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