Aims Up to 40% of patients with gastro-esophageal reflux disease (GERD) do not respond to medical therapy. Laparoscopic fundoplication (LF) for GERD provides suboptimal outcomes and risk of long-lasting adverse events. Transoral incisionless fundoplication (TIF) may be proposed as alternative treatment for GERD. TIF and LF long-term effects have not been compared so far, to assess the real efficacy of TIF in clinical practice. We aimed at comparing the long-term outcomes of TIF and 360 LF or partial (anterior 90 to 180 or posterior 270) LF in GERD patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Methods A systematic search of major databases was performed up to September 2025. Studies reporting 5-to 10-year outcomes of TIF and LF in patients with confirmed GERD were included. Randomized controlled trials comparing 360 and partial LF were considered. Pooled proportions and 95 …
Long-term efficacy of transoral incisionless and surgical laparoscopic fundoplication for treatment of gastro-esophageal reflux disease: a systematic-review and comparative meta-analysis / Testoni, S.G., Contu, F., Pantaleo, G., Passaretti, S., Cavestro, G.M., De Luca, L., Testoni, P.A.. - In: ENDOSCOPY. - ISSN 0013-726X. - 58:S 03(2026). [10.1055/s-0046-1821111]
Long-term efficacy of transoral incisionless and surgical laparoscopic fundoplication for treatment of gastro-esophageal reflux disease: a systematic-review and comparative meta-analysis
Testoni, SG G
;Contu, F;Pantaleo, G;Cavestro, G M;Testoni, P A
2026-01-01
Abstract
Aims Up to 40% of patients with gastro-esophageal reflux disease (GERD) do not respond to medical therapy. Laparoscopic fundoplication (LF) for GERD provides suboptimal outcomes and risk of long-lasting adverse events. Transoral incisionless fundoplication (TIF) may be proposed as alternative treatment for GERD. TIF and LF long-term effects have not been compared so far, to assess the real efficacy of TIF in clinical practice. We aimed at comparing the long-term outcomes of TIF and 360 LF or partial (anterior 90 to 180 or posterior 270) LF in GERD patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Methods A systematic search of major databases was performed up to September 2025. Studies reporting 5-to 10-year outcomes of TIF and LF in patients with confirmed GERD were included. Randomized controlled trials comparing 360 and partial LF were considered. Pooled proportions and 95 …I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
