Introduction Erectile dysfunction (ED) is a common complaint in men over 40 years of age, and prevalence rates increase throughout the aging period. Prevalence and risk factors of ED among young men have been scantly analyzed. Aim Assessing sociodemographic and clinical characteristics of young men (defined as 40 years) seeking first medical help for new onset ED as their primary sexual disorder. Methods Complete sociodemographic and clinical data from 439 consecutive patients were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the International Index of Erectile Function (IIEF). Main Outcome Measure Descriptive statistics tested sociodemographic and clinical differences between ED patients 40 years and >40 years. Results New onset ED as the primary disorder was found in 114 (26%) men 40 years (mean [standard deviation [SD]] age: 32.4 [6.0]; range: 17-40 years). Patients 40 years had a lower rate of comorbid conditions (CCI=0 in 90.4% vs. 58.3%; (2), 39.12; P<0.001), a lower mean body mass index value (P=0.005), and a higher mean circulating total testosterone level (P=0.005) as compared with those >40 years. Younger ED patients more frequently showed habit of cigarette smoking and use of illicit drug, as compared with older men (all P0.02). Premature ejaculation was more comorbid in younger men, whereas Peyronie's disease was prevalent in the older group (all P=0.03). At IIEF, severe ED rates were found in 48.8% younger men and 40% older men, respectively (P>0.05). Similarly, rates of mild, mild-to-moderate, and moderate ED were not significantly different between the two groups. Conclusions This exploratory analysis showed that one in four patients seeking first medical help for new onset ED was younger than 40 years. Almost half of the young men suffered from severe ED, with comparable rates in older patients. Overall, younger men differed from older individuals in terms of both clinical and sociodemographic parameters. Capogrosso P, Colicchia M, Ventimiglia E, Castagna G, Clementi MC, Suardi N, Castiglione F, Briganti A, Cantiello F, Damiano R, Montorsi F, and Salonia A. One patient out of four with newly diagnosed erectile dysfunction is a young manworrisome picture from the everyday clinical practice. J Sex Med 2013;10:1833-1841.
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