BACKGROUND AND OBJECTIVE: The aim of the study was to ascertain whether photodynamic therapy (PDT) with verteporfin is able to reduce the blood-aqueous barrier impairment in eyes affected by pseudoexfoliative glaucoma (PESG) with consequent intraocular pressure (IOP) lowering. PATIENTS AND METHODS: Five patients with poorly controlled PESG were selected. The laser energy was directed to the anterior chamber angle and the iris surface by means of a Goldmann lens. RESULTS: IOP reduction was registered 1 month after PDT and lasted 3 months, reaching the values registered before PDT after that. Iris fluorescein angiography 1 week and 1 month after PDT showed reduced dye leakage, but the same amount of dye leakage visible before PDT was detectable 3 months later. CONCLUSION: PDT can reduce the breakdown of the blood-aqueous barrier and can lower the IOP temporarily in eyes affected by PESG. Further studies are needed to analyze the biochemical changes after PDT in aqueous humor.

Temporary Intraocular Pressure Lowering by Photodynamic Therapy in Pseudoexfoliation Glaucoma

Parodi MB;BANDELLO , FRANCESCO
2011

Abstract

BACKGROUND AND OBJECTIVE: The aim of the study was to ascertain whether photodynamic therapy (PDT) with verteporfin is able to reduce the blood-aqueous barrier impairment in eyes affected by pseudoexfoliative glaucoma (PESG) with consequent intraocular pressure (IOP) lowering. PATIENTS AND METHODS: Five patients with poorly controlled PESG were selected. The laser energy was directed to the anterior chamber angle and the iris surface by means of a Goldmann lens. RESULTS: IOP reduction was registered 1 month after PDT and lasted 3 months, reaching the values registered before PDT after that. Iris fluorescein angiography 1 week and 1 month after PDT showed reduced dye leakage, but the same amount of dye leakage visible before PDT was detectable 3 months later. CONCLUSION: PDT can reduce the breakdown of the blood-aqueous barrier and can lower the IOP temporarily in eyes affected by PESG. Further studies are needed to analyze the biochemical changes after PDT in aqueous humor.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/4403
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