"Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients"
Transarterial Chemoembolization with Drug-eluting Beads Preloaded with Irinotecan as a First-Line Approach in Uveal Melanoma Liver Metastases: Tumor Response and Predictive Value of Diffusion-weighted MR Imaging in Five Patients.
Ratti, F;Aldrighetti, L;DE COBELLI, FRANCESCOPenultimo
;DEL MASCHIO, ALESSANDROUltimo
2012-01-01
Abstract
"Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients"I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.