The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response.
Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder / Benedetti, Francesco; Poletti, Sara; Hoogenboezem, Thomas A; Locatelli, Clara; de Wit, Harm; Wijkhuijs, Annemarie J. M; Colombo, CRISTINA ANNA; Drexhage, Hemmo A.. - In: JOURNAL OF CLINICAL PSYCHIATRY. - ISSN 0160-6689. - (2017). [Epub ahead of print] [10.4088/JCP.16m11310]
Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder
Benedetti, Francesco;POLETTI, SARASecondo
;COLOMBO, CRISTINA ANNAPenultimo
;
2017-01-01
Abstract
The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
