Variants in the CACNA1A gene on chromosome 19p13 result in a spectrum of neurological phenotypes ranging from familial or sporadic hemiplegic migraine to congenital or progressive encephalopathies. Patients with CACNA1A variants often show acute attacks with ataxia or hemiplegia till coma, sometimes related to unilateral brain oedema. No guidelines for the medical management of these attacks are available since treatment is empiric, and many cases do not respond to common antimigraine drugs.
Combined early treatment in hemiplegic attacks related to CACNA1A encephalopathy with brain oedema: Blocking the cascade? / Camia, F., Pisciotta, L., Morana, G., Schiaffino, M.C., Renna, S., Carrera, P., Ferrari, M., Baglietto, M.G., Veneselli, E., Siri, L., Mancardi, M.M.. - In: CEPHALALGIA. - ISSN 0333-1024. - 37:12(2017), pp. 1202-1206. [10.1177/0333102416668655]
Combined early treatment in hemiplegic attacks related to CACNA1A encephalopathy with brain oedema: Blocking the cascade?
FERRARI, MAURIZIO;
2017-01-01
Abstract
Variants in the CACNA1A gene on chromosome 19p13 result in a spectrum of neurological phenotypes ranging from familial or sporadic hemiplegic migraine to congenital or progressive encephalopathies. Patients with CACNA1A variants often show acute attacks with ataxia or hemiplegia till coma, sometimes related to unilateral brain oedema. No guidelines for the medical management of these attacks are available since treatment is empiric, and many cases do not respond to common antimigraine drugs.| File | Dimensione | Formato | |
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cephalgia 2017.pdf
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