Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis / Rosendahl, Jonas; Kirsten, Holger; Hegyi, Eszter; Kovacs, Peter; Weiss, Frank Ulrich; Laumen, Helmut; Lichtner, Peter; Ruffert, Claudia; Chen, Jian min; Masson, Emmanuelle; Beer, Sebastian; Zimmer, Constantin; Seltsam, Katharina; Algül, Hana; Bühler, Florence; Bruno, Marco J; Bugert, Peter; Burkhardt, Ralph; Cavestro, GIULIA MARTINA; Cichoz lach, Halina; Farré, Antoni; Frank, Josef; Gambaro, Giovanni; Gimpfl, Sebastian; Grallert, Harald; Griesmann, Heidi; Grützmann, Robert; Hellerbrand, Claus; Hegyi, Péter; Hollenbach, Marcus; Iordache, Sevastitia; Jurkowska, Grazyna; Keim, Volker; Kiefer, Falk; Krug, Sebastian; Landt, Olfert; Leo, Milena Di; Lerch, Markus M; Lévy, Philippe; Löffler, Markus; Löhr, Matthias; Ludwig, Maren; Macek, Milan; Malats, Nuria; Malecka panas, Ewa; Malerba, Giovanni; Mann, Karl; Mayerle, Julia; Mohr, Sonja; Te Morsche, Rene H. M; Motyka, Marie; Mueller, Sebastian; Müller, Thomas; Nöthen, Markus M; Pedrazzoli, Sergio; Pereira, Stephen P; Peters, Annette; Pfützer, Roland; Real, Francisco X; Rebours, Vinciane; Ridinger, Monika; Rietschel, Marcella; Rösmann, Eva; Saftoiu, Adrian; Schneider, Alexander; Schulz, Hans ulrich; Soranzo, Nicole; Soyka, Michael; Simon, Peter; Skipworth, James; Stickel, Felix; Strauch, Konstantin; Stumvoll, Michael; Testoni, PIER ALBERTO; Tönjes, Anke; Werner, Lena; Werner, Jens; Wodarz, Norbert; Ziegler, Martin; Masamune, Atsushi; Mössner, Joachim; Férec, Claude; Michl, Patrick; Joost, P. H. Drenth; Witt, Heiko; Scholz, Markus; Sahin tóth, Miklós. - In: GUT. - ISSN 0017-5749. - (2018), pp. 1855-1863. [10.1136/gutjnl-2017-314454]
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
CAVESTRO, GIULIA MARTINA;TESTONI, PIER ALBERTO;
2018-01-01
Abstract
Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
