The aim of this study was to define the time structure of leg movements during sleep occurring with an intermovement interval (onset-to-onset) shorter than 10Â s in patients with restless legs syndrome and controls, and to compare it to the structure of movements with intervals of 10â90Â s or >90Â s. Polysomnographic recordings of 141 untreated patients and 68 age-matched normal controls were analysed. All movements were detected and classified into three categories, separated by intervals of <10, 10â90 or >90Â s. The number of movements included in each category was significantly higher in patients than in controls. The movements with an interval of >90Â s occurred steadily during the night, whereas the hourly distribution of movements with intervals of <10 or 10â90Â s was decreasing or bell-shaped in patients or controls, respectively. Movements with an interval of <10Â s tended to have a shorter duration and constituted shorter sequences than movements with intervals of 10â90 or >90Â s. The time structure features of the three categories of movements considered in this study were found to be clearly different. This, together with previous observations on the differential effects of dopamine agonists on movements with different intervals, suggests that movements with intervals of <10 and >90Â s are regulated by neurotransmitter mechanisms different from those modulating movements with an interval of 10â90Â s.
Sequence analysis of leg movements during sleep with different intervals (<10, 10â 90 and >90Â s) in restless legs syndrome / Ferri, Raffaele; Rundo, Francesco; Silvani, Alessandro; Zucconi, Marco; Aricò, Debora; Bruni, Oliviero; Cosentino, Filomena I. I.; Ferini-Strambi, Luigi; Manconi, Mauro. - In: JOURNAL OF SLEEP RESEARCH. - ISSN 0962-1105. - 26:4(2017), pp. 436-443. [10.1111/jsr.12500]
Sequence analysis of leg movements during sleep with different intervals (<10, 10â90 and >90Â s) in restless legs syndrome
Ferini-Strambi, Luigi;
2017-01-01
Abstract
The aim of this study was to define the time structure of leg movements during sleep occurring with an intermovement interval (onset-to-onset) shorter than 10Â s in patients with restless legs syndrome and controls, and to compare it to the structure of movements with intervals of 10â90Â s or >90Â s. Polysomnographic recordings of 141 untreated patients and 68 age-matched normal controls were analysed. All movements were detected and classified into three categories, separated by intervals of <10, 10â90 or >90Â s. The number of movements included in each category was significantly higher in patients than in controls. The movements with an interval of >90Â s occurred steadily during the night, whereas the hourly distribution of movements with intervals of <10 or 10â90Â s was decreasing or bell-shaped in patients or controls, respectively. Movements with an interval of <10Â s tended to have a shorter duration and constituted shorter sequences than movements with intervals of 10â90 or >90Â s. The time structure features of the three categories of movements considered in this study were found to be clearly different. This, together with previous observations on the differential effects of dopamine agonists on movements with different intervals, suggests that movements with intervals of <10 and >90Â s are regulated by neurotransmitter mechanisms different from those modulating movements with an interval of 10â90Â s.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.