Fluorescein angiography and indocyanine green videoangiography in the iris of pseudoexfoliation syndrome

The precise evaluation of iris vascular pattern in pseudoexfoliation syndrome (PXS) may be difficult on iris fluorescein angiography (IFA) because of the frequent presence of a heavily pigmented iris and late conspicuous leakage. Thanks to its special characteristics, iris indocyanine green videoangiography (IICGV) is able precisely to visualize details of the iris vascular pattern. The aim of the study is to analyze the feasibility of IICGV in detecting microvascular changes in PXS and compare these findings with those of IFA. Twenty-eight patients affected in both eyes by PXS underwent an ophthalmologic examination including IFA and IICGV. IICGV was performed using IMAGEnet system H1024. A better visualization of iris hypoperfusion and anastomotic vessels was obtained on IICGV, whereas iris microneovascularization was far more clearly visible on IFA. Moreover, iris pigment epithelium defects were detectable on IICGV. IICGV may be considered a useful tool in the evaluation of the iris vascular pattern in PXS. Iris hypoperfusion could not play a contributory role in the development of iris microvascular changes.