Obesity is one of the main rising causes of health problems in modern society and is correlated to type 2 diabetes mellitus, hypertension, heart disease and atherosclerosis. Bacterial products, endogenous substances such as oxidized LDL (ox-LDL) and heat shock proteins mediate activation of Toll-like receptors and reinforce the view that the innate immune system plays a key role in the genesis of atherosclerosis. In addition, natural killer T (NKT) cells respond to lipids presented via CD1d on APCs, and may also be able to affect atherosclerosis. All the main cell types involved in atherosclerosis such as endothelial cells, macrophages, T cells, smooth muscle cells and platelets express proinfammatory cytokines. In addition, CD4 ligation triggers the expression of adhesion molecules, cytokines and matrix metalloprotinease. IL-6 cytokines travels to the liver where it elicits acute phase response resolving in the release of serum amyloid-A C-reactive protein, fbrogen and plasminogen activator inhibitor-1. Therefore increasing body fat mass is associated with high levels of infammatory cytokines such as IL-1 and TNF. In this study we revisit the interrelationship between fat and infammation.
cholesterol: an inflammatory compound / A., Saggini; A., Anogeianaki; D., Angelucci; E., Cianchetti; M., D’Alessandro; G., Maccauro; Salini, Vincenzo; A., Caraffa; Tete', Stefano; Conti, Fiorella; Tripodi, Domenico; Fulcheri, Mario; S., Frydas; M., Rosati; Y. B., SHAIK DASTHAGIRISAHEB. - In: EUROPEAN JOURNAL OF INFLAMMATION. - ISSN 1721-727X. - 9:(2011), pp. 209-217.
cholesterol: an inflammatory compound
SALINI, VINCENZO;
2011-01-01
Abstract
Obesity is one of the main rising causes of health problems in modern society and is correlated to type 2 diabetes mellitus, hypertension, heart disease and atherosclerosis. Bacterial products, endogenous substances such as oxidized LDL (ox-LDL) and heat shock proteins mediate activation of Toll-like receptors and reinforce the view that the innate immune system plays a key role in the genesis of atherosclerosis. In addition, natural killer T (NKT) cells respond to lipids presented via CD1d on APCs, and may also be able to affect atherosclerosis. All the main cell types involved in atherosclerosis such as endothelial cells, macrophages, T cells, smooth muscle cells and platelets express proinfammatory cytokines. In addition, CD4 ligation triggers the expression of adhesion molecules, cytokines and matrix metalloprotinease. IL-6 cytokines travels to the liver where it elicits acute phase response resolving in the release of serum amyloid-A C-reactive protein, fbrogen and plasminogen activator inhibitor-1. Therefore increasing body fat mass is associated with high levels of infammatory cytokines such as IL-1 and TNF. In this study we revisit the interrelationship between fat and infammation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
