IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis because of the T cells and macrophages that invade the synovial fluid. These finding support a role for IL-18 in inflammation, allergy and immune diseases.

Impact of IL-18 on inflammation / Domenico, T., Anogeianaki, A., Castellani Maria, L., Felaco, P., Toniato, E., De Lutiis, M.A., Fulcheri, M., Tete', S., Salini, V., Frydas, I., Sabatino, G., Shaik-Dasthagirisaheb, Y.B.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 25:1(2011), pp. 7-11.

Impact of IL-18 on inflammation

Salini Vincenzo;
2011-01-01

Abstract

IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis because of the T cells and macrophages that invade the synovial fluid. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
2011
Autoimmunity; Immunoregulation; Inflammation; Interleukin-18; Lymphocytes
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/87035
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