Cytokines are immunomodulatory and infammatory compounds produced by many different cell types. The IL-1 family consists of at least eleven cytokines including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate infammation. IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells. IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE. Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and infammation. Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4. Here we review the interrelationship between PGD2, IL-1 family members and mast cells.
PGD2, IL1-FAMILY MEMBERS AND MAST CELLS / Anogeianaki, A.; Castellani, M. L.; Tripodi, D.; Felaco, P.; Toniato, E.; DE LUTIIS, M. A.; Fulcheri, M.; Tetè, S.; Galzio, R.; Salini, V.; Caraffa, A.; Antinolfi, P.; Frydas, I.; Sabatino, G.; SHAIK-DASTHAGIRISAHEB, Y. B.. - In: EUROPEAN JOURNAL OF INFLAMMATION. - ISSN 1721-727X. - 8:(2010), pp. 137-142.
PGD2, IL1-FAMILY MEMBERS AND MAST CELLS
V. SALINI;
2010-01-01
Abstract
Cytokines are immunomodulatory and infammatory compounds produced by many different cell types. The IL-1 family consists of at least eleven cytokines including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate infammation. IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells. IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE. Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and infammation. Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4. Here we review the interrelationship between PGD2, IL-1 family members and mast cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
